A recent study highlights the untapped potential of grape stems from the Douro region, traditionally considered waste, as rich sources of bioactive compounds like selenium, tryptophan, and polyphenols. Touriga Nacional stood out for its high antioxidant capacity and nutrient content. These compounds have promising applications in cognitive health, mood regulation, and oxidative stress prevention. The study supports a circular economy approach in the wine industry, reducing waste while opening new economic opportunities. However, challenges such as extraction efficiency, regulatory approval, and market acceptance must be addressed. Future efforts should focus on product development, consumer education, and investment in innovation to fully harness the benefits of grape stem-derived compounds.